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Sequestration shapes the response of signal transduction cascades
Author(s) -
Blüthgen Nils
Publication year - 2006
Publication title -
iubmb life
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.132
H-Index - 113
eISSN - 1521-6551
pISSN - 1521-6543
DOI - 10.1080/15216540600994340
Subject(s) - signal transduction , phosphatase , transduction (biophysics) , enzyme , mechanism (biology) , microbiology and biotechnology , signal (programming language) , kinase , chemistry , biology , biophysics , biochemistry , physics , computer science , quantum mechanics , programming language
Many signal transduction cascades are composed of covalent modification cycles such as kinase/phosphatase cycles. In the 1980s Goldbeter and Koshland showed that such cycles can exhibit non‐linear input‐output relations when the enzymes are saturated by their substrates, which may facilitate signal processing. Recent papers show that this mechanism is unlikely to cause non‐linearity in mammalian signal transduction cascades as sequestration of the target due to enzyme concentrations present in these cascades will hamper this mechanism. However, sequestration due to high‐affinity enzymes can shape the dynamics and steady‐state behaviour of signal transduction cascades in different ways, some of which are discussed in this review.iubmb Life, 58: 659 ‐ 663, 2006