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ERK1/2 MAP kinases in cell survival and apoptosis
Author(s) -
Lu Zhimin,
Xu Shuichan
Publication year - 2006
Publication title -
iubmb life
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.132
H-Index - 113
eISSN - 1521-6551
pISSN - 1521-6543
DOI - 10.1080/15216540600957438
Subject(s) - kinase , mitogen activated protein kinase , apoptosis , microbiology and biotechnology , phosphatase , subfamily , mapk/erk pathway , biology , phosphorylation , biochemistry , gene
ERK1/2 is an important subfamily of mitogen‐activated protein kinases that control a broad range of cellular activities and physiological processes. ERK1/2 can be activated transiently or persistently by MEK1/2 and upstream MAP3Ks in conjunction with regulation and involvement of scaffolding proteins and phosphatases. Activation of ERK1/2 generally promotes cell survival; but under certain conditions, ERK1/2 can have pro‐apoptotic functions.iubmb Life, 58: 621 ‐ 631, 2006