Premium
Red blood cells in the metabolism of nitric oxide‐derived peroxynitrite
Author(s) -
Romero Natalia,
Denicola Ana,
Radi Rafael
Publication year - 2006
Publication title -
iubmb life
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.132
H-Index - 113
eISSN - 1521-6551
pISSN - 1521-6543
DOI - 10.1080/15216540600936549
Subject(s) - peroxynitrite , nitric oxide , chemistry , nitrotyrosine , superoxide , biochemistry , peroxynitrous acid , oxidative phosphorylation , metabolism , oxidative stress , biophysics , nitric oxide synthase , biology , organic chemistry , enzyme
In this review we have analyzed the reactions of nitric oxide (·NO) with superoxide radical (O2·‐) at the vascular compartment which results in limitation of the bioavailability of ·NO and the formation of peroxynitrite (ONOO‐), a strong oxidant species. The intravascular formation of peroxynitrite can result in oxidative modifications of plasma and vessel wall proteins including the formation of protein‐3‐nitrotyrosine. The role of red blood cells (RBC) and oxyhemoglobin in the metabolism of intravascular peroxynitrite will be discussed. While RBC constitute an important 'sink' of both ·NO and peroxynitrite, redox reactions of these species with oxyhemoglobin may in part contribute to erythrocyte aging. The intravascular formation, reactions and detoxification of peroxynitrite are revealed as important factors controlling vascular dysfunction and degeneration in a variety of pathophysiologically‐relevant conditions.iubmb Life, 58: 572‐580, 2006