RNase L: Its biological roles and regulation | Zendy

Liang ShuLing | Zendy; Quirk David | Zendy; Zhou Aimin | Zendy

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RNase L: Its biological roles and regulation

Author(s) -

Liang ShuLing,

Quirk David,

Zhou Aimin

Publication year - 2006

Publication title -

iubmb life

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.132

H-Index - 113

eISSN - 1521-6551

pISSN - 1521-6543

DOI - 10.1080/15216540600838232

Subject(s) - rnase p , ribonuclease , innate immune system , biology , function (biology) , activator (genetics) , microbiology and biotechnology , enzyme , rna , computational biology , immune system , genetics , biochemistry , gene

2'‐5'oligoadenylate‐dependent ribonuclease L (RNase L) is one of the key enzymes involved in the function of interferons (IFNs), a family of cytokines participating in innate immunity against viruses and other microbial pathogens. Upon binding with its activator, 5'‐phosphorylated, 2'‐5' linked oligoadenylates (2‐5A), RNase L degrades single‐stranded viral and cellular RNAs and thus plays an important role in the antiviral and antiproliferative functions of IFNs. In recent years, evidence has revealed that RNase L displays a broad range of biological roles which are summarized in this review.iubmb Life, 58: 508‐514, 2006

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