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RNase L: Its biological roles and regulation
Author(s) -
Liang ShuLing,
Quirk David,
Zhou Aimin
Publication year - 2006
Publication title -
iubmb life
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.132
H-Index - 113
eISSN - 1521-6551
pISSN - 1521-6543
DOI - 10.1080/15216540600838232
Subject(s) - rnase p , ribonuclease , innate immune system , biology , function (biology) , activator (genetics) , microbiology and biotechnology , enzyme , rna , computational biology , immune system , genetics , biochemistry , gene
2'‐5'oligoadenylate‐dependent ribonuclease L (RNase L) is one of the key enzymes involved in the function of interferons (IFNs), a family of cytokines participating in innate immunity against viruses and other microbial pathogens. Upon binding with its activator, 5'‐phosphorylated, 2'‐5' linked oligoadenylates (2‐5A), RNase L degrades single‐stranded viral and cellular RNAs and thus plays an important role in the antiviral and antiproliferative functions of IFNs. In recent years, evidence has revealed that RNase L displays a broad range of biological roles which are summarized in this review.iubmb Life, 58: 508‐514, 2006