Premium
Historical view of DNA replication studies, with special reference to Japan
Author(s) -
Sugino Akio,
Araki Hiroyuki
Publication year - 2006
Publication title -
iubmb life
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.132
H-Index - 113
eISSN - 1521-6551
pISSN - 1521-6543
DOI - 10.1080/15216540600732070
Subject(s) - okazaki fragments , replication (statistics) , lagging , dna replication , key (lock) , replicate , biology , dna , computational biology , computer science , genetics , virology , eukaryotic dna replication , mathematics , ecology , statistics
Almost forty years after the key contributions to the field by Okazaki and coworkers that gave rise to the concept of leading and the lagging strand, we are still at the state of uncertainty about the proteins that replicate each strand. Perhaps, one main conclusion that should be drawn from the data currently available is that the protein architecture at the fork is more plastic than originally thought.iubmb Life, 58: 323‐327, 2006