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Nectins and nectin‐like molecules: Roles in cell adhesion, polarization, movement, and proliferation
Author(s) -
Ogita Hisakazu,
Takai Yoshimi
Publication year - 2006
Publication title -
iubmb life
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.132
H-Index - 113
eISSN - 1521-6551
pISSN - 1521-6543
DOI - 10.1080/15216540600719622
Subject(s) - nectin , adherens junction , microbiology and biotechnology , cell adhesion molecule , cadherin , cell adhesion , cell–cell interaction , integrin , immunoglobulin superfamily , biology , cell polarity , cell , chemistry , genetics
Abstract Nectins and nectin‐like molecules (Necls) are immunoglobulin‐like cell adhesion molecules that constitute families containing four and five members, respectively. All members, except for Necl‐5, trans‐interact homophilically. Furthermore, all members, including Necl‐5, trans‐interact heterophilically with their respective specific partners among the members. Necl‐5 regulates cell movement and proliferation cooperatively with integrin αvβ3 and growth factor receptors. Nectins function as cell‐cell adhesion molecules at a variety of cell‐cell junctions, including adherens junctions, and regulate the initial step of cell‐cell junction formation. Nectins and integrin αvβ3 are further involved in the cross‐talk between cell‐matrix and cell‐cell junctions. Thus, both nectin and Necl family members play important roles in fundamental cellular functions, including cell adhesion, polarization, movement, and proliferation.iubmb Life, 58: 334‐343, 2006