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Stochastic proton pumping ATPases: From single molecules to diverse physiological roles
Author(s) -
NakanishiMatsui Mayumi,
Futai Masamitsu
Publication year - 2006
Publication title -
iubmb life
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.132
H-Index - 113
eISSN - 1521-6551
pISSN - 1521-6543
DOI - 10.1080/15216540600702255
Subject(s) - atp synthase , atpase , f atpase , proton , protein subunit , proton transport , proton pump , biophysics , chemistry , gene isoform , molecular motor , biochemistry , membrane , biology , enzyme , physics , gene , thylakoid , chloroplast , quantum mechanics
We discuss the most recent reports on two proton pumps, F‐ATPase (ATP synthase) and V‐ATPase (endomembrane proton pump). They are formed from similar extrinsic (F1 or V1) and intrinsic (Fo or Vo) membrane sectors, and couple chemistry and proton transport through subunit rotation for apparently different physiological roles. Emphasis is placed on the stochastic rotational catalysis of F‐ATPase and isoforms of V‐ATPase.iubmb Life, 58: 318‐322, 2006