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Toll‐like receptor signaling and IRF transcription factors
Author(s) -
Honda Kenya,
Taniguchi Tadatsugu
Publication year - 2006
Publication title -
iubmb life
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.132
H-Index - 113
eISSN - 1521-6551
pISSN - 1521-6543
DOI - 10.1080/15216540600702206
Subject(s) - interferon regulatory factors , innate immune system , biology , interferon , transcription factor , toll like receptor , immune system , acquired immune system , receptor , transcription (linguistics) , immunology , context (archaeology) , gene , pattern recognition receptor , signal transduction , microbiology and biotechnology , genetics , paleontology , linguistics , philosophy
Interferon regulatory factors (IRFs) were originally discovered in the context of type I interferon (IFN‐α/β) gene induction, and subsequent studies on these transcription factors have revealed their remarkable functional diversity in regulating immune systems. Indeed, the critical involvement of IRF members in innate and adaptive immune responses has recently gained much attention, particularly with the recent discovery of Toll‐like receptors (TLRs) and analyses of their critical functions in linking the innate and adaptive immune responses.iubmb Life, 58: 290‐295, 2006