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Engineered bio‐nanocapsules, the selective vector for drug delivery system
Author(s) -
Yu Dongwei,
Fukuda Takayuki,
Kuroda Shun'ichi,
Tanizawa Katsuyuki,
Kondo Akihiko,
Ueda Masakazu,
Yamada Tadanori,
Tada Hiroko,
Seno Masaharu
Publication year - 2006
Publication title -
iubmb life
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.132
H-Index - 113
eISSN - 1521-6551
pISSN - 1521-6543
DOI - 10.1080/15216540500484368
Subject(s) - nanocapsules , drug delivery , drug , targeted drug delivery , nanotechnology , vector (molecular biology) , chemistry , pharmacology , microbiology and biotechnology , biology , materials science , biochemistry , recombinant dna , nanoparticle , gene
The bio‐nanocapsule (BNC) is our concept of artificial hollow nanoparticles that have been designed and produced through biotechnological procedures. We proposed an empty virus‐like particle, which consists of a recombinant L envelope protein of hepatitis B virus (HBV) and a lipid derived from the host cell, as an engineered BNC. Although this BNC was first developed as an immunogen of hepatitis B vaccine, the pre‐S1 region in N‐terminus of L envelope protein confers hepatocyte specific infectivity of HBV on the BNC. This recombinant BNC is now being developed as a novel platform of drug delivery system (DDS) vector for selective delivery.IUBMB Life, 58: 1 ‐ 6, 2006