Engineered bio‐nanocapsules, the selective vector for drug delivery system | Zendy

Yu Dongwei | Zendy; Fukuda Takayuki | Zendy; Kuroda Shun'ichi | Zendy; Tanizawa Katsuyuki | Zendy; Kondo Akihiko | Zendy; Ueda Masakazu | Zendy; Yamada Tadanori | Zendy; Tada Hiroko | Zendy; Seno Masaharu | Zendy

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Engineered bio‐nanocapsules, the selective vector for drug delivery system

Author(s) -

Yu Dongwei,

Fukuda Takayuki,

Kuroda Shun'ichi,

Tanizawa Katsuyuki,

Kondo Akihiko,

Ueda Masakazu,

Yamada Tadanori,

Tada Hiroko,

Seno Masaharu

Publication year - 2006

Publication title -

iubmb life

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.132

H-Index - 113

eISSN - 1521-6551

pISSN - 1521-6543

DOI - 10.1080/15216540500484368

Subject(s) - nanocapsules , drug delivery , drug , targeted drug delivery , nanotechnology , vector (molecular biology) , chemistry , pharmacology , microbiology and biotechnology , biology , materials science , biochemistry , recombinant dna , nanoparticle , gene

The bio‐nanocapsule (BNC) is our concept of artificial hollow nanoparticles that have been designed and produced through biotechnological procedures. We proposed an empty virus‐like particle, which consists of a recombinant L envelope protein of hepatitis B virus (HBV) and a lipid derived from the host cell, as an engineered BNC. Although this BNC was first developed as an immunogen of hepatitis B vaccine, the pre‐S1 region in N‐terminus of L envelope protein confers hepatocyte specific infectivity of HBV on the BNC. This recombinant BNC is now being developed as a novel platform of drug delivery system (DDS) vector for selective delivery.IUBMB Life, 58: 1 ‐ 6, 2006

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