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The Ganglioside GD3 as the Greek Goddess Hecate: Several Faces Turned Towards as Many Directions
Author(s) -
Malisan Florence,
Testi Roberto
Publication year - 2005
Publication title -
iubmb life
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.132
H-Index - 113
eISSN - 1521-6551
pISSN - 1521-6543
DOI - 10.1080/15216540500167179
Subject(s) - intracellular , apoptosis , microbiology and biotechnology , mitochondrion , ganglioside , chemistry , cell , biology , biochemistry
The disialoganglioside GD3 can mediate biological functions as diverse as proliferation, differentiation, and apoptosis. Since intracellular level of GD3 is crucial for the cell, understanding the mechanisms by which GD3 metabolism is tightly regulated seems of particular importance. GD3 can be enlisted among the most potent natural inducers of mitochondrial damage and apoptosis. However, some cell types resist GD3‐mediated mitochondrial damage through complex mechanisms which are beginning to be unveiled.IUBMB Life, 57: 477‐482, 2005