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Reactive Oxygen Species as Mediators of Cellular Senescence
Author(s) -
Colavitti Renata,
Finkel Toren
Publication year - 2005
Publication title -
iubmb life
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.132
H-Index - 113
eISSN - 1521-6551
pISSN - 1521-6543
DOI - 10.1080/15216540500091890
Subject(s) - senescence , reactive oxygen species , epigenetics , organism , biology , microbiology and biotechnology , function (biology) , signal transduction , signalling pathways , intracellular , genetics , gene
Aging has often been viewed as a random process arising from the accumulation of both genetic and epigenetic changes. Increasingly, the notion that aging is a stochastic process is being supplanted by the concept that maximum lifespan of an organism is tightly regulated. This knowledge has led to a growing overlap between classical signal transduction paradigms and the biology of aging. We review certain specific examples where these seemingly disparate disciplines intersect. In particular, we review the concept that intracellular reactive oxygen species function as signalling molecules and that oxidants play a central role as mediators of cellular senescence.IUBMB Life, 57: 277‐281, 2005