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On the Existence of Cellular Tocopheryl Phosphate, its Synthesis, Degradation and Cellular Roles: A Hypothesis
Author(s) -
Negis Yesim,
Zingg JeanMarc,
Ogru Esra,
Gianello Robert,
Libinaki Roksan,
Azzi Angelo
Publication year - 2005
Publication title -
iubmb life
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.132
H-Index - 113
eISSN - 1521-6551
pISSN - 1521-6543
DOI - 10.1080/15216540500058980
Subject(s) - phosphate , hydrolysis , chemistry , tocopherol , degradation (telecommunications) , molecule , alpha tocopherol , biochemistry , mechanism of action , cell signaling , tocopheryl acetate , signal transduction , vitamin e , organic chemistry , antioxidant , in vitro , telecommunications , computer science
The finding that α‐tocopheryl phosphate is present in cells in small amounts, that it can be synthesized and hydrolyzed supports the hypothesis that α‐tocopheryl phosphate might be a signaling molecule. The possible pathways needed for the synthesis, hydrolysis and signaling are considered in this hypothesis as well the possible extension of this reaction to additional molecules such as tocopherols and tocotrienols. A possible mechanism of action of other tocopherol esters (succinate and maleate) is also hypothesized.IUBMB Life, 57: 23‐25, 2005