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Viruses and the Development of Quantitative Biological Electron Microscopy
Author(s) -
Crowther RA
Publication year - 2004
Publication title -
iubmb life
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.132
H-Index - 113
eISSN - 1521-6551
pISSN - 1521-6543
DOI - 10.1080/15216540412331279996
Subject(s) - biological specimen , computer science , electron microscope , nanotechnology , computational biology , biochemical engineering , biology , materials science , optics , engineering , physics , ecology
The electron microscope has become an important tool for determining the structure of biological materials of all kinds. Many technical advances in specimen preparation and in sophisticated methods of image analysis, initially based on optical systems but latterly on computer processing, have contributed to the development of the subject. Viruses of various kinds have often provided a convenient and appropriate test specimen. This paper describes the major technical advances and shows how viruses have had an important role in most of the developments.IUBMB Life, 56: 239‐248, 2004