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Trophic Factors in Neurodegenerative Disorders
Author(s) -
Weis Joachim,
Saxena Smita,
Evangelopoulos Maria,
Kruttgen Alex
Publication year - 2003
Publication title -
iubmb life
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.132
H-Index - 113
eISSN - 1521-6551
pISSN - 1521-6543
DOI - 10.1080/1521654031000153021
Subject(s) - neuroscience , neurotrophin , neurotrophic factors , axoplasmic transport , neurite , trophic level , amyotrophic lateral sclerosis , disease , brain derived neurotrophic factor , stimulation , biology , neurodegeneration , receptor , medicine , ecology , biochemistry , in vitro
Neuronal survival is dependent on continuous trophic stimulation by neurotrophic factors. Anterograde and retrograde transport of neurotrophic factors and their receptors within neurites is essential for the communication of these survival signals. Lack of neurotrophic input has been proposed as a pathomechanism leading to neurodegenerative disease. The present short review provides a summary of some of the recent data on neurotrophic factors in neurodegenerative disorders and describes how disturbances of axonal trafficking might deprive neurons from trophic input. IUBMB Life, 55: 00‐00, 2003