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HIF‐1 and AP‐1 Cooperate to Increase Gene Expression in Hypoxia: Role of MAP Kinases
Author(s) -
Michiels Carine,
Minet Emmanuel,
Michel Gaetan,
Mottet Denis,
Piret JeanPascal,
Raes Martine
Publication year - 2001
Publication title -
iubmb life
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.132
H-Index - 113
eISSN - 1521-6551
pISSN - 1521-6543
DOI - 10.1080/15216540252774766
Subject(s) - hypoxia (environmental) , kinase , transcription factor , gene expression , gene , glycolysis , microbiology and biotechnology , hypoxia inducible factors , transcription (linguistics) , hypoxia inducible factor 1 , erythropoietin , mapk/erk pathway , mitogen activated protein kinase , biology , chemistry , enzyme , biochemistry , genetics , oxygen , organic chemistry , linguistics , philosophy
HIF‐1 is the main transcription factor responsible for increased gene expression in hypoxia: VEGF, erythropoietin, GLUT‐1, and glycolytic enzymes are such target genes and all participate in the adaptative response of cells to hypoxia. AP‐1 activation by hypoxia has also been demonstrated in several cell lines and it cooperates with HIF‐1 for increasing VEGF gene transcription in hypoxia. Both HIF‐1 and AP‐1 activation by hypoxia seems to involve members of the MAP kinase family. Here, we summarize the data indicating that ERK and JNK are needed for activation of HIF‐1 and AP‐1, respectively.