Premium
The Role of Troponins in Muscle Contraction
Author(s) -
Gomes Aldrin V.,
Potter James D.,
SzczesnaCordary Danuta
Publication year - 2002
Publication title -
iubmb life
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.132
H-Index - 113
eISSN - 1521-6551
pISSN - 1521-6543
DOI - 10.1080/15216540216037
Subject(s) - troponin , contraction (grammar) , muscle contraction , medicine , cardiology , myocardial infarction
Troponin (Tn) is the sarcomeric Ca 2+ regulator for striated (skeletal and cardiac) muscle contraction. On binding Ca 2+ Tn transmits information via structural changes throughout the actin‐tropomyosin filaments, activating myosin ATPase activity and muscle contraction. Although the Tn‐mediated regulation of striated muscle contraction is now well understood, the role of different Tn isoforms in these processes is the subject of intensive investigations. This review addresses the physiological significance of the multiple Tn isoforms in skeletal and cardiac muscles as well as their role in the regulation of contraction.