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RNA‐Binding Proteins That Target the Androgen Receptor mRNA
Author(s) -
Wilce Jackie A.,
Leedman Peter J.,
Wilce Matthew C. J.
Publication year - 2002
Publication title -
iubmb life
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.132
H-Index - 113
eISSN - 1521-6551
pISSN - 1521-6543
DOI - 10.1080/15216540216033
Subject(s) - messenger rna , androgen receptor , rna , microbiology and biotechnology , rna binding protein , biology , gene , computational biology , chemistry , genetics , prostate cancer , cancer
Recent efforts to elucidate mechanisms of posttranscriptional gene regulation have resulted in the description of both cis ‐ and trans ‐acting factors which affect the stability and translational efficiency of specific mRNAs. Here we summarise some of the concepts in this field, with particular attention to recently discovered protein/RNA interactions involving the human androgen receptor mRNA. Such systems are of interest for their potential as targets for the modulation of protein production.