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Do Hemoglobin and Hemocyanin Impair Schistosoma Killing by NO?
Author(s) -
Ascenzi Paolo,
Fasano Mauro,
Gradoni Luigi
Publication year - 2002
Publication title -
iubmb life
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.132
H-Index - 113
eISSN - 1521-6551
pISSN - 1521-6543
DOI - 10.1080/15216540213467
Subject(s) - hemocyanin , hemoglobin , myoglobin , protozoa , biology , schistosoma , neuroglobin , antiparasitic , antiparasitic agent , nitric oxide , malaria , microbiology and biotechnology , immunology , biochemistry , schistosoma mansoni , globin , helminths , antibody , pharmacology , medicine , schistosomiasis , pathology , endocrinology
Nitric oxide (NO) possesses antiparasitic effects on both Protozoa and Metazoa in definitive and intermediate hosts as well as in vectors. Here, we postulate that hemoglobin and hemocyanin may impair Schistosoma killing by NO in the definitive and intermediate hosts. Interestingly, hemoglobin, myoglobin, and neuroglobin may protect Plasmodium and Trypanosoma from the antiparasitic effects of NO.