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Inositol Polyphosphate 5‐Phosphatases: Lipid Phosphatases With Flair
Author(s) -
Mitchell Christina A.,
Gurung Rajendra,
Kong Anne M.,
Dyson Jennifer M.,
Tan April,
Ooms Lisa M.
Publication year - 2002
Publication title -
iubmb life
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.132
H-Index - 113
eISSN - 1521-6551
pISSN - 1521-6543
DOI - 10.1080/15216540210815
Subject(s) - polyphosphate , phosphatase , inositol , biochemistry , yeast , microbiology and biotechnology , enzyme , endocytosis , insulin receptor , chemistry , biology , cell , insulin , receptor , endocrinology , insulin resistance , phosphate
Recent studies have identified the inositol polyphosphate 5‐phosphatases as a large family of signal modifying enzymes comprising 10 mammalian and 4 yeast family members. A number of investigations including gene‐targeted deletion of 5‐phosphatases in mice have demonstrated that these enzymes regulate many important cellular events including hematopoietic cell proliferation and activation, insulin signaling, endocytosis, and actin polymerization.