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Mitochondrial Calcium Homeostasis: Mechanisms and Molecules
Author(s) -
Vandecasteele Grégoire,
Szabadkai György,
Rizzuto Rosario
Publication year - 2001
Publication title -
iubmb life
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.132
H-Index - 113
eISSN - 1521-6551
pISSN - 1521-6543
DOI - 10.1080/15216540152846028
Subject(s) - endoplasmic reticulum , mitochondrion , microbiology and biotechnology , organelle , function (biology) , biology , homeostasis , calcium signaling , biochemistry , signal transduction
Despite the early characterisation of Ca 2+ fluxes in isolated mitochondria and the ability of this ion to up‐regulate dehydrogenases of the Krebs cycle, the low affinity of the organelle uptake pathways was a long‐standing obstacle to the recognition of a physiological role for mitochondrial Ca 2+ uptake. This review begins with a historical account of the main results that proved the contrary and provides a brief description of mitochondrial Ca 2+ signals. Then, it discusses the characteristics of Ca 2+ regulation of mitochondrial function. Finally, it summarizes recent discoveries on structural aspects of mitochondrial reticulum and its connections to signalling partners such as the endoplasmic reticulum or the plasma membrane.