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The Mitochondrial Complex I: Progress in Understanding of Catalytic Properties
Author(s) -
Vinogradov Andrei D.,
Grivennikova Vera G.
Publication year - 2001
Publication title -
iubmb life
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.132
H-Index - 113
eISSN - 1521-6551
pISSN - 1521-6543
DOI - 10.1080/15216540152845920
Subject(s) - mitochondrion , respiratory chain , mitochondrial respiratory chain , catalysis , chemistry , transition (genetics) , electron transport complex i , computational biology , biology , biophysics , biochemistry , microbiology and biotechnology , gene
Although the mitochondrial Complex I has been extensively studied for over 4 decades, its catalytic properties in mitochondria are poorly understood. This review summarizes the data on standard and nonstandard kinetic parameters of the enzyme. The slow interconversion between active and deactivated forms of the mammalian Complex I (A/D transition) is described. We discuss the potential relevance of this transition for the regulation of NADH oxidation by the respiratory chain under physiological and pathophysiological conditions.