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Genomic Organization of BmTXKβ and BmTXKS2, Two Scorpion Venom Peptides From Buthus martensii Karsch
Author(s) -
Cao Zhijian,
Zhu Shunyi,
Li Wenxin,
Jiang Dahe,
He Xiaohua,
Liu Hui
Publication year - 2001
Publication title -
iubmb life
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.132
H-Index - 113
eISSN - 1521-6551
pISSN - 1521-6543
DOI - 10.1080/152165401317190815
Subject(s) - scorpion , venom , intron , gene , coding region , biology , scorpion venoms , signal peptide , genetics , scorpion toxin , peptide , microbiology and biotechnology , computational biology , peptide sequence , biochemistry
Toelucidate genomic organization of BmTXK βand BmTXKS2, two scorpion venom peptides from Chinese scorpion Buthus martensii Karsch(BmK) were first isolated and their genomic regions characterized using the PCR method. Analysis of nucleotide sequence shows that there exists different intron location in the venom genes. The region encoding mature peptide of BmTXK βis disrupted by an intron with 886 bp, whereas the intron of BmTXKS2 is located within its propeptide coding region, which is different from other scorpion toxin genes with their introns within the signal peptide coding region.