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Transient Up‐Regulation of Liver Mitochondrial Thymidine Kinase Activity in Proliferating Mitochondria
Author(s) -
Elholm Morten,
HollÅs Hanne,
Issalene Carol,
Barroso Joao Filipe Viegas,
Berge Rolf Kristian,
Flatmark Torgeir
Publication year - 2001
Publication title -
iubmb life
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.132
H-Index - 113
eISSN - 1521-6551
pISSN - 1521-6543
DOI - 10.1080/15216540119294
Subject(s) - peroxisome , mitochondrion , organelle , thymidine kinase , thymidine , enzyme , chemistry , kinase , microbiology and biotechnology , biochemistry , biology , gene , immunology , dna , virus , herpes simplex virus
Administration of the fatty acid analogue tetradecylthioacetic acid (TTA) to rodents up‐regulates peroxisomal and mitochondrial lipid‐metabolizing enzymes and induces a proliferation of these organelles in hepatocytes. We show here that male NMRI mice fed a diet containing 0.3% (w/w) TTA revealed a transient two‐fold increase in the incorporation of [3
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