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Casein Kinase I: From Obscurity to Center Stage
Author(s) -
Vielhaber Erica,
Virshup David M.
Publication year - 2001
Publication title -
iubmb life
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.132
H-Index - 113
eISSN - 1521-6551
pISSN - 1521-6543
DOI - 10.1080/15216540117461
Subject(s) - casein kinase 1 , kinase , wnt signaling pathway , biology , serine , casein kinase 2 , threonine , microbiology and biotechnology , protein kinase a , phosphorylation , signal transduction , cyclin dependent kinase 2
Abstract The casein kinase I (CKI) family of protein kinases is a group of highly related, ubiquitously expressed serine/threonine kinases found in all eukaryotic organisms from protozoa to man. Recent advances in diverse fields, including developmental biology and chronobiology, have elucidated roles for CKI in regulating critical processes such as Wnt signaling, circadian rhythm, nuclear import, and Alzheimer's disease progression.