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Establishing a Left‐Right Axis in the Embryo
Author(s) -
Ryan Aimee K.,
Belmonte Juan Carlos Izpisúa
Publication year - 2000
Publication title -
iubmb life
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.132
H-Index - 113
eISSN - 1521-6551
pISSN - 1521-6543
DOI - 10.1080/15216540050176520
Subject(s) - anatomy , biology , embryo , left and right , function (biology) , evolutionary biology , microbiology and biotechnology , structural engineering , engineering
Vertebrates exhibit evolutionarily conserved asymmetries in the pattern of internal organ placement that are essential for their normal physiological function. Left‐right asymmetries in organ situs are dependent upon the formation of an intact left‐right axis during embryogenesis. Recently many of the molecular components involved in the initiation and maintenance of the left‐right axis have been described. These molecules and their function in promoting left‐right asymmetries are reviewed.