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Transport of Mitochondria During Axonogenesis
Author(s) -
Dedov Vadim N.,
Dedova Irina V.,
Armati Patricia J.
Publication year - 2000
Publication title -
iubmb life
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.132
H-Index - 113
eISSN - 1521-6551
pISSN - 1521-6543
DOI - 10.1080/15216540050167115
Subject(s) - mitochondrion , neurite , dorsal root ganglion , microbiology and biotechnology , biophysics , chemistry , hillock , biology , anatomy , dorsum , biochemistry , materials science , in vitro , composite material
The cellular mechanisms involved in axonogenesis are still unclear. In the present work we found that formation of neurites in cultured neonatal dorsal root ganglion neurons co‐incided with the redistribution of highly charged mitochondria. Radially distributed in subplasmalemmal space 3 h after plating, highly charged mitochondria formed clusters in the hillocks of predominant neurites during the next 24?48 h and then redistributed into the axons. These results provide evidence that accumulation of a critical mass of charged mitochondria at the site of the future axonal hillock may represent the slow initiation stage of axonogenesis, followed by a fast growth phase.