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Epidermal Growth Factor Receptor Signal Transactivation
Author(s) -
Leserer Michael,
Gschwind Andreas,
Ullrich Axel
Publication year - 2000
Publication title -
iubmb life
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.132
H-Index - 113
eISSN - 1521-6551
pISSN - 1521-6543
DOI - 10.1080/152165400410254
Subject(s) - transactivation , epidermal growth factor receptor , microbiology and biotechnology , g protein coupled receptor , epidermal growth factor , biology , signal transduction , receptor , growth factor receptor inhibitor , growth factor receptor , heterologous , computational biology , cancer research , genetics , transcription factor , gene
Cross‐communication between heterologous signaling systems and the epidermal growth factor receptor (EGFR) has been shown to be critical for a variety of biological responses: EGFR transactivation when G‐protein‐coupled receptors (GPCRs) are stimulated represents the paradigm of an interreceptor network that is dependent on G‐proteins, kinases, metalloproteases, and growth factor precursors. Investigating the mechanism of this process will help expand our knowledge of physiological regulatory mechanisms and diverse pathophysiological disorders.