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Putative Mechanism for Anticancer and Apoptosis‐Inducing Properties of Plant‐Derived Polyphenolic Compounds
Author(s) -
Hadi S. M.,
Asad S. F.,
Singh Saurabh,
Ahmad Aamir
Publication year - 2000
Publication title -
iubmb life
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.132
H-Index - 113
eISSN - 1521-6551
pISSN - 1521-6543
DOI - 10.1080/152165400300001471
Subject(s) - polyphenol , curcumin , resveratrol , chemistry , antioxidant , apoptosis , mechanism of action , mechanism (biology) , endogeny , biochemistry , cancer cell , cancer , pharmacology , biology , in vitro , philosophy , epistemology , genetics
Several plant‐derived polyphenolic compounds are considered to possess anticancer and apoptosis‐inducing properties in cancer cells. Such compounds are recognized as naturally occurring antioxidants but also exhibit prooxidant properties under appropriate conditions. Evidence in the literature suggests that the antioxidant properties of polyphenolics such as gallotannins, curcumin, and resveratrol may not fully account for their chemopreventive effects. We propose a mechanism for the cytotoxic action of these compounds against cancer cells that involves mobilization of endogenous copper and the consequent prooxidant action.