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Cocaethylene: effects on brain systems and behavior
Author(s) -
HOROWITZ JUDITH M.,
TORRES GERMAN
Publication year - 1999
Publication title -
addiction biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.445
H-Index - 78
eISSN - 1369-1600
pISSN - 1355-6215
DOI - 10.1080/13556219971632
Subject(s) - neuroscience , psychology
Cocaethylene is a psychoactive metabolite formed during the combined consumption of cocaine and ethanol. In this brief review, we discuss several well‐characterized effects of this metabolite with an emphasis on the neurobiological and behavioral correlates of polydrug addiction. Included herein are the descriptions of some of the changes in trans‐synaptic transmission and their relationship to pathological behaviors associated with a chronic, drug‐dependent state that may be altered by the spatial or temporal dynamics of cocaethylene.