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Antisocial tendencies in alcohol‐dependent men and their relation to harman, salsolinol and dopamine
Author(s) -
PODSCHUS JAN,
DUFEU PETER,
SCHMIDT LUTZ G.,
SALLSTROMBAUM SIEDY,
ROMMELSPACHER HANS
Publication year - 1997
Publication title -
addiction biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.445
H-Index - 78
eISSN - 1369-1600
pISSN - 1355-6215
DOI - 10.1080/13556219772886
Subject(s) - psychology , personality , antisocial personality disorder , novelty seeking , dopamine , reward dependence , empathy , clinical psychology , psychiatry , poison control , big five personality traits , injury prevention , neuroscience , medicine , social psychology , medical emergency
Abstract Plasma dopamine, β‐carbolines (norharman, harman) and isoquinolines ((R)‐ and (S)‐salsolinol) were examined for their relationship to antisocial tendencies in 138 drinking men with an alcohol dependence syndrome according to ICD‐10 criteria. Antisociality was assessed according to the following criteria: delinquency, involvement in fist‐fights and homelessness. The personality structure was documented by the Tridimensional Personality Questionnaire of Cloninger. An early age of onset of alcohol dependence and a high degree of ‘novelty seeking’ were associated with antisocial tendencies. Of the β‐carbolines and isoquinolines, harman and (S)‐salsolinol were significantly decreased among antisocial alcoholics. Norharman, (R)‐salsolinol and dopamine were not associated with antisocial personality. The contribution of endogenous alkaloids to the biological characterization of antisocial tendencies in alcoholics is described.