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Do smoking intensity‐related differences in vigilance indicate altered glucocorticoid receptor sensitivity?
Author(s) -
Reuter Martin,
Hennig Juergen,
Netter Petra
Publication year - 2004
Publication title -
addiction biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.445
H-Index - 78
eISSN - 1369-1600
pISSN - 1355-6215
DOI - 10.1080/13556210410001674077
Subject(s) - nicotine , endocrinology , mineralocorticoid receptor , glucocorticoid , medicine , vigilance (psychology) , placebo , glucocorticoid receptor , dexamethasone , flicker fusion threshold , mineralocorticoid , psychology , receptor , flicker , neuroscience , electrical engineering , alternative medicine , engineering , pathology
The relationship of critical flicker fusion frequency (CFF) and a pharmacologically induced cortisol suppression by means of dexamethasone (DEX) and metyrapone (MET) was investigated during nicotine deprivation in a between‐subjects design in 60 male smokers divided into light, medium and heavy smokers. DEX reduced vigilance in medium smokers and improved it in heavy smokers compared to placebo, whereas MET was more detrimental in heavy smokers. The hypothesis was put forward that the intensity of nicotine consumption is related to differences in glucocorticoid and mineralocorticoid receptor sensitivity.