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Alcohol dehydrogenase ADH2–1 and ADH2–2 allelic isoforms in the Russian population correlate with type of alcoholic disease
Author(s) -
Ogurtsov Pavel P.,
Garmash Irina V.,
Miandina Galina I.,
Guschin Alexander E.,
Itkes Alexander V.,
Moiseev Valentin S.
Publication year - 2001
Publication title -
addiction biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.445
H-Index - 78
eISSN - 1369-1600
pISSN - 1355-6215
DOI - 10.1080/13556210020077109
Subject(s) - alcoholic liver disease , cirrhosis , allele , genotype , population , alcohol dehydrogenase , alcoholic hepatitis , medicine , gastroenterology , alcohol , biology , genetics , gene , environmental health , biochemistry
The frequency ADH2‐2 allele in the Moscow urban population and a correlation between the ADH2‐2 allele, alcoholic dependence without cirrhosis, symptomatic alcoholic cirrhosis and status on hepatitis B and C infection have been studied. One hundred and twenty‐three inhabitants of Moscow (50 healthy donors, 36 patients with alcoholic cirrhosis (subdivided into infected and uninfected by HBV and/or HCV) and 37 patients with alcoholic dependence) of a similar age/sex and drinking pattern have been analysed. The frequency of 41% for ADH2‐2 allele is characteristic for an urban Moscow population. This value is intermediate between that found for Asian peoples and for Central and Western Europe. There is a negative correlation between the ADH2‐2 allele and alcohol misuse (both alcoholic dependence and alcoholic cirrhosis). This correlation is expressed more in alcoholic dependence. In spite of the possession of the ADH2‐2 allele (or genotype ADH2‐1/2), alcohol misuse increases the risk of cirrhosis. At the same time, positive status for active hepatitis B, C or combined infection B + C (replication markers HBV‐DNA or HCV‐RNA) increases the risk for symptomatic alcoholic cirrhosis in alcohol abusing patients, independently of ADH2 genotype.