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A putative sigma 1 receptor antagonist NE‐100 attenuates the discriminative stimulus effects of ketamine in rats
Author(s) -
Narita Minoru,
Yoshizawa Kazumi,
Aoki Kazue,
Takagi Misa,
Miyatake Mayumi,
Suzuki Tsutomu
Publication year - 2001
Publication title -
addiction biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.445
H-Index - 78
eISSN - 1369-1600
pISSN - 1355-6215
DOI - 10.1080/13556210020077091
Subject(s) - ketamine , stimulus control , psychotomimetic , antagonist , sigma , stimulus (psychology) , pharmacology , receptor , nmda receptor , sigma 1 receptor , receptor antagonist , medicine , neuroscience , anesthesia , psychology , physics , psychotherapist , agonist , quantum mechanics , nicotine
Abstract Ketamine, one of the dissociative anaesthetic agents, has been shown to produce psychotomimetic effects. It has been well documented that activation of sigma receptors is responsible for the pathogenesis of some psychiatric disorders. In the present study, the effects of NE‐100, a putative sigma 1 receptor antagonist, was investigated in rats trained to discriminate between ketamine (5 mg/kg, i.p.) from saline under a fixed‐ratio 10 food‐reinforced procedure. Here we report for the first time that NE‐100 (1 mg/kg) produced a shift to the right in the dose–response curve for ketamine's discriminative stimulus effects. These results suggest that the sigma 1 receptor is, at least in part, involved in the discriminative stimulus effects of ketamine.