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RBC Adhesion to Vascular Endothelial Cells: More Potent than RBC Aggregation in Inducing Circulatory Disorders
Author(s) -
YEDGAR SAUL,
KAUL DHANANJAY K.,
BARSHTEIN GREGORY
Publication year - 2008
Publication title -
microcirculation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.793
H-Index - 83
eISSN - 1549-8719
pISSN - 1073-9688
DOI - 10.1080/10739680802105482
Subject(s) - circulatory system , adhesion , in vivo , microcirculation , erythrocyte aggregation , blood vessel , chemistry , microbiology and biotechnology , vascular wall , biology , biophysics , medicine , biochemistry , genetics , organic chemistry , fibrinogen
Growing evidence has suggested that the adhesion of red blood cells (RBCs) to blood vessel wall endothelial cells (ECs) is a potent catalyst of microcirculatory disorders, but direct in vivo documentation has been lacking. In a recent study we have demonstrated the elevation of vascular resistance by RBCs with increased adhesion to ECs and normal deformability in the absence of aggregation. Unlike the previous chapter (i.e., the “point”), the findings and considerations discussed in this chapter (the “counterpoint) imply that RBC/EC adhesion is a more potent determinant of circulatory disorders than RBC aggregation.