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Peritubular Capillary Loss Is Ameliorated by Ramipril or Valsartan Treatment
Author(s) -
Zhang Bin,
Chen Nan,
Shi Wei,
Wang Weiming,
Shi Hao,
Yu Haijin
Publication year - 2008
Publication title -
microcirculation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.793
H-Index - 83
eISSN - 1549-8719
pISSN - 1073-9688
DOI - 10.1080/10739680701743540
Subject(s) - ramipril , valsartan , capillary action , medicine , cardiology , pharmacology , materials science , blood pressure , composite material
Objective : To identify the preservation of peritubular capillaries conferred by ramipril or valsartan treatment as an additional mechanism for their renoprotection. Methods : The effect of ramipril or valsartan on peritubular capillaries was investigated in a remnant kidney model using male Sprague‐Dawley rats sacrificed post‐operatively at 3, 6 and 12 weeks respectively. Peritubular capillaries and tubulointerstitial hypoxia in untreated remnant kidney rats ( n = 26), remnant kidney rats treated with ramipril ( n = 22, 0.5 mg/kg/day), valsartan ( n = 22, 30 mg/kg/day) or amlodipine ( n = 22, 30 mg/kg/day) and sham‐operated rats ( n = 22) were assessed by CD141 and HIF‐1α staining. Results : Ramipril or valsartan significantly preserved the peritubular capillaries as well as renal function ( p < 0.01). Tubulointerstitial hypoxia and tubular TGF‐β expression were noted well before the development of tubulointerstitial damage. The gentler slope of the relationship between HIF‐1α scores and peritubular capillary density in individual rats was noted in both ramipril‐treated and valsartan‐treated groups compared to the untreated remnant kidney group ( p < 0.05). Conclusions : Amelioration of peritubular capillary loss and subsequent tubular hypoxia by ramipril or valsartan treatment should be interpreted as an alternative type of their renoprotection, one which also implies a novel focus for clinical intervention.