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Retrospective Safety Analysis of Atomoxetine in Adult ADHD Patients with or without Comorbid Alcohol Abuse and Dependence
Author(s) -
Adler Lenard,
Wilens Timothy,
Zhang Shuyu,
Durell Todd,
Walker Daniel,
Schuh Leslie,
Jin Ling,
Feldman Peter,
Trzepacz Paula
Publication year - 2009
Publication title -
the american journal on addictions
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.997
H-Index - 76
eISSN - 1521-0391
pISSN - 1055-0496
DOI - 10.1080/10550490903077663
Subject(s) - atomoxetine , psychiatry , alcohol abuse , medicine , alcohol , retrospective cohort study , attention deficit hyperactivity disorder , clinical psychology , psychology , methylphenidate , chemistry , biochemistry
This post hoc analysis compared the safety of atomoxetine treatment of ADHD in adults with or without comorbid alcohol abuse/dependence. Study completion rates in patients receiving atomoxetine were comparable between heavy drinkers (60.9%) and patients with no alcohol‐use disorder (71.0%) but lower in nonheavy drinkers (35.7%); however, there was no significant difference in discontinuation rates due to adverse events or lack of efficacy among these groups. Alcohol‐use disorder patients, especially heavy drinkers, generally experienced the greatest frequency of treatment‐emergent adverse events in both the atomoxetine and placebo groups. Vital signs and measures of hepatic function were not significantly different among the 3 drinking status groups taking atomoxetine.