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Auditory P300 Event‐Related Potentials and Neurocognitive Functions in Opioid Dependent Men and Their Brothers
Author(s) -
Singh Shubh Mohan,
Basu Debasish,
Kohli Adarsh,
Prabhakar Sudesh
Publication year - 2009
Publication title -
the american journal on addictions
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.997
H-Index - 76
eISSN - 1521-0391
pISSN - 1055-0496
DOI - 10.1080/10550490902786975
Subject(s) - endophenotype , wisconsin card sorting test , psychology , neurocognitive , event related potential , executive functions , cognition , memory span , executive dysfunction , opioid , audiology , cognitive flexibility , developmental psychology , neuroscience , medicine , neuropsychology , working memory , receptor
Event‐related‐potentials (especially P300) and cognitive functioning as potential endophenotypes have not been studied in opioid dependence. We compared auditory P300 and cognitive functions in opioid‐dependent men, their brothers and normal controls in an exploratory study with a view to find shared genetic factors in the development of opioid dependence. Twenty abstinent opioid‐dependent males, their brothers and twenty matched controls were administered Wisconsin card sorting test (WCST), digit span test, trail making test‐B, and auditory event‐related potentials (P300) from an oddball task were recorded. The opioid dependent group performed the worst, the brothers group was intermediate, and the control group performed the best on tests of WCST, digit span and trail making test‐B. The opioid dependent group had the smallest amplitudes and longest latencies of P300, and was followed by the brothers group who had an intermediate position and the control group who had the largest amplitudes and the shortest latencies. P300 and executive neurocognitive functions can be considered endophenotypes for the genetic study of vulnerability to opioid dependence. These are reflective of executive dysfunction and disrupted behavioral inhibition and the intermediate position of brothers suggests a common genetic substrate as a component of the etiology.