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Gender Differences in Predictors of Treatment Attrition with High Dose Naltrexone in Cocaine and Alcohol Dependence
Author(s) -
Suh Jesse J.,
Pettinati Helen M.,
Kampman Kyle M.,
O'Brien Charles P.
Publication year - 2008
Publication title -
the american journal on addictions
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.997
H-Index - 76
eISSN - 1521-0391
pISSN - 1055-0496
DOI - 10.1080/10550490802409074
Subject(s) - naltrexone , discontinuation , attrition , nausea , alcohol dependence , psychiatry , clinical psychology , psychology , alcohol , medicine , cocaine dependence , addiction , antagonist , biochemistry , chemistry , receptor , dentistry
Recently, we reported that naltrexone at 150 mg/day significantly decreased cocaine and alcohol use for men but not women with co‐occurring cocaine and alcohol dependence. The present study is an exploratory investigation of predictors that explain the different gender responses to naltrexone, with a particular focus on differential predictors of treatment attrition. No significant predictors were associated with treatment discontinuation in men. Women, however, were more likely to discontinue treatment when reporting severe pre‐treatment psychiatric problems or nausea while in treatment. Further research on the impact of pre‐treatment and in‐treatment gender differences with naltrexone is warranted.