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Early Abstinence in Cocaine Dependence: Influence of Comorbid Major Depression
Author(s) -
Rubin Eric,
Aharonovich Efrat,
Bisaga Adam,
Levin Frances R.,
Raby Wilfrid N.,
Nunes Edward V.
Publication year - 2007
Publication title -
the american journal on addictions
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.997
H-Index - 76
eISSN - 1521-0391
pISSN - 1055-0496
DOI - 10.1080/10550490701389880
Subject(s) - abstinence , depression (economics) , psychology , psychiatry , cocaine dependence , clinical psychology , medicine , addiction , economics , macroeconomics
Cocaine dependence (CD) is often accompanied by major depressive disorder (MDD). The comorbid condition (CD + MDD) is especially difficult to treat, with relapse possibly made more likely by intensified dysphoria during abstinence in the setting of MDD. We studied treatment‐seeking CD + MDD volunteers, currently depressed, and a comparison CD group over three days of inpatient monitored abstinence. At admission, Beck Depression Inventory (BDI) and anxiety scores differed significantly between groups. By Day 3, BDI scores improved for both CD and CD + MDD groups. The mood response to cocaine cessation among CD + MDD individuals resembled that of CD participants, contrary to some expectations.