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Family History of Psychiatric Disorders and Alcohol and Substance Misuse in Patients with Bipolar I Disorder, Substance Use Disorder, or Both
Author(s) -
Sbrana Alfredo,
Bizzarri Jacopo V.,
Rucci Paola,
Gonnelli Chiara,
Massei Jacopo G.,
Ravani Laura,
Endicott Jean,
Maser Jack D.,
Cassano Giovanni B.
Publication year - 2007
Publication title -
the american journal on addictions
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.997
H-Index - 76
eISSN - 1521-0391
pISSN - 1055-0496
DOI - 10.1080/10550490701375699
Subject(s) - first degree relatives , bipolar disorder , psychiatry , family history , substance abuse , medicine , alcohol use disorder , alcohol , psychology , mood , biochemistry , chemistry
Family history data were collected on first‐degree relatives of 78 patients with bipolar I disorder (BD) and substance use disorder (SUD), 47 with BD only, and 35 with SUD only. The prevalence of psychiatric disorders was significantly higher in first‐degree relatives of patients with BD + SUD (64%) and BD (61%) compared with first‐degree relatives of SUD patients (20%). The prevalence of alcohol misuse was significantly higher in first‐degree relatives of patients with BD + SUD (23.1%) and SUD alone (28.6%) compared to first‐degree relatives of patients with BD (4.3%). Our findings suggest that BD and SUD do not share familial risk factors.