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Serotonin Transporter Genotype and Acute Subjective Response to Amphetamine
Author(s) -
Lott David C.,
Kim SooJeong,
Cook Edwin H.,
Wit Harriet.
Publication year - 2006
Publication title -
the american journal on addictions
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.997
H-Index - 76
eISSN - 1521-0391
pISSN - 1055-0496
DOI - 10.1080/10550490600859868
Subject(s) - serotonin transporter , amphetamine , dopamine transporter , genotype , psychology , affect (linguistics) , placebo , 5 httlpr , dopamine , crossover study , serotonin , addiction , medicine , pharmacology , psychiatry , genetics , gene , biology , neuroscience , dopaminergic , communication , alternative medicine , receptor , pathology
The authors have previously shown an effect of dopamine transporter genotype on acute subjective responses to d‐amphetamine, which may affect risk of addiction. They now report the results of an evaluation of the role of the serotonin transporter gene (HTT) using a double‐blind, placebo‐controlled, crossover design in which subjects (N = 101) completed self‐report measures of subjective effect. The separate and combined analyses of the gene‐linked polymorphic region (5‐HTTLPR) and the Intron 2 VNTR suggest that these two HTT polymorphisms may contribute to acute subjective responses to d‐amphetamine with a small effect.