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Substance Use Disorder Comorbidity in Major Depressive Disorder: A Confirmatory Analysis of the STAR*D Cohort
Author(s) -
Davis Lori L.,
Frazier Elizabeth,
Husain Mustafa M.,
Warden Diane,
Trivedi Madhukar,
Fava Maurizio,
Cassano Paolo,
McGrath Patrick J.,
Balasubramani G. K.,
Wisniewski Stephen R.,
Rush A. John
Publication year - 2006
Publication title -
the american journal on addictions
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.997
H-Index - 76
eISSN - 1521-0391
pISSN - 1055-0496
DOI - 10.1080/10550490600754317
Subject(s) - depression (economics) , major depressive disorder , comorbidity , cohort , psychiatry , demographics , anxiety , substance abuse , medicine , clinical psychology , psychology , demography , mood , sociology , economics , macroeconomics
The demographics and clinical features were compared between those with (29.4%) and without concurrent substance use disorder (SUD) in 2541 outpatients with major depression (MDD) enrolled in the Sequenced Treatment Alternatives to Relieve Depression study. Compared to those without SUD, MDD patients with concurrent SUD were more likely to be younger, male, divorced or never married, and at greater current suicide risk, and have an earlier age of onset of depression, greater depressive symptomatology, more previous suicide attempts, more frequent concurrent anxiety disorders, and greater functional impairment ( p = 0.048 to < 0.0001). They were also less likely to be Hispanic and endorse general medical comorbidities ( p = 0.006 and 0.002, respectively).