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Atypical Antipsychotic Medication and Substance Use‐Related Outcomes in the Treatment of Schizophrenia
Author(s) -
Petrakis Ismene L.,
Leslie Douglas,
Finney John W.,
Rosenheck Robert
Publication year - 2006
Publication title -
the american journal on addictions
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.997
H-Index - 76
eISSN - 1521-0391
pISSN - 1055-0496
DOI - 10.1080/10550490500419052
Subject(s) - veterans affairs , schizophrenia (object oriented programming) , substance abuse , psychiatry , atypical antipsychotic , antipsychotic , addiction , medicine , multivariate analysis , bipolar disorder , clinical psychology , psychology , mood
Using national administrative data from the Department of Veterans Affairs (VA), clinical change in veterans with schizophrenia and comorbid substance abuse and dependence (n=249) was assessed with the Addiction Severity Index. Outcomes among those switched or maintained on an atypical antipsychotic were compared with those treated with conventionals. For the entire sample and those on an atypical during the last assessment, paired t‐tests showed significant decreases in the alcohol and psychological ASI scores. However, multivariate analysis showed no greater improvement in alcohol, drug, or psychological scores in individuals who were switched to (n=33) or maintained on (n=161) an atypical antipsychotic as compared to those who were treated with conventional at the final assessment (n=55). Patients treated with atypical antipsychotics achieved no greater improvement in substance‐related outcomes that patients who were not.