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Sensitization to the Psychosis‐Inducing Effects of Cocaine Compared with Measures of Cocaine Craving and Cue Reactivity
Author(s) -
Reid Malcolm S.,
Ciplet Debra,
O'Leary Siobhan,
Branchey Marc,
BuydensBranchey Laure,
Angrist Burt
Publication year - 2004
Publication title -
the american journal on addictions
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.997
H-Index - 76
eISSN - 1521-0391
pISSN - 1055-0496
DOI - 10.1080/10550490490460175
Subject(s) - craving , cue reactivity , psychosis , sensitization , addiction , cocaine dependence , psychology , cocaine use , reactivity (psychology) , clinical psychology , psychiatry , medicine , neuroscience , alternative medicine , pathology
A previous study has suggested that sensitization to the psychosis‐inducing effects of cocaine may be a marker of vulnerability to relapse in cocaine addiction. In this report, cocaine‐dependent subjects participating in a study on naturally occurring and cue‐induced cocaine craving were interviewed about prior experience of cocaine‐induced psychosis and the degree to which this effect had become more frequent or severe or had occurred at lower cumulative doses. Sensitization to cocaine‐induced psychosis was negatively correlated with baseline measures of drug dependence severity and indices of cocaine craving over the preceding 24 hours but not with measures of cocaine cue reactivity.