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Gender Differences in Response to Sertraline Pharmacotherapy in Type A Alcohol Dependence
Author(s) -
Pettinati Helen M.,
Dundon William,
Lipkin Craig
Publication year - 2004
Publication title -
the american journal on addictions
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.997
H-Index - 76
eISSN - 1521-0391
pISSN - 1055-0496
DOI - 10.1080/10550490490459906
Subject(s) - sertraline , pharmacotherapy , alcohol dependence , alcohol , psychology , clinical psychology , medicine , psychiatry , chemistry , antidepressant , anxiety , biochemistry
We previously established that Babor Type A “lower‐risk / severity” alcoholics ( n = 55) had better treatment response to fourteen weeks of sertraline (200 mg/ day) than placebo, a finding not present for Type B “higher‐risk /severity” alcoholics ( n = 45). This exploratory study extended these results by examining the original sample for gender differences in response to sertraline pharmacotherapy. Type A alcoholic men, but not Type A alcoholic women, had consistently better outcomes with sertraline compared to placebo on several common drinking measures: time to relapse, days drinking, days drinking heavily, drinks per drinking day, and number of those continually abstinent. There were no significant differences in drinking with sertraline compared to placebo in Type B alcoholic men or women.