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Effects of HIV Triple Therapy on Methadone Levels
Author(s) -
Akerele Evaristo O.,
Levin Frances,
Nunes Edward,
Brady Ronald,
Kleber Herbert
Publication year - 2002
Publication title -
the american journal on addictions
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.997
H-Index - 76
eISSN - 1521-0391
pISSN - 1055-0496
DOI - 10.1080/1055049029008810
Subject(s) - methadone , medicine , substitution therapy , human immunodeficiency virus (hiv) , pharmacotherapy , pharmacology , immunology
There is a belief among methadone patients that triple therapy for HIV reduces methadone potency. This cross‐sectional study compared the rate of methadone metabolism (peak‐trough blood levels) in two groups of methadone‐maintained patients, AIDS patients receiving triple therapy (N = 17), and HIV patients without triple therapy (N = 19). These preliminary findings suggest that triple therapy may increase the rate of methadone metabolism, though further studies are warranted.