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Isradipine Enhancement of Cerebral Blood Flow in Abstinent Cocaine Abusers with and without Chronic Perfusion Deficits
Author(s) -
Gottschalk P.C.H.,
Kosten Thomas R.
Publication year - 2002
Publication title -
the american journal on addictions
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.997
H-Index - 76
eISSN - 1521-0391
pISSN - 1055-0496
DOI - 10.1080/10550490290087983
Subject(s) - cerebral blood flow , isradipine , perfusion , medicine , anesthesia , perfusion scanning , cardiology , hemodynamics , psychology , receptor , antagonist
Nine cocaine abusers with cerebral blood flow (CBF) deficits (hypo‐perfused areas) on HMPAO SPECT scans were compared to six without these deficits after six doses of isradipine (5 mg TID). When comparing the scan before isradipine to that after using SPM analysis, the ratio of hypo‐ to hyper‐fusion showed a 16% increase in the maximum Z scores and 30% fewer areas of hypo‐perfusion among those cocaine abusers with deficits. These deficits may represent segmental cerebral vasospasm that was reversed by this vasodilating agent in cocaine abusers with areas of hypo‐perfusion (deficits) as baseline.