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The Validity of Self‐Reported Drug Use in Non‐Treatment Seeking Individuals with Cocaine Dependence: Correlation with Biochemical Assays
Author(s) -
Elman Igor,
Krause Sara,
Breiter Hans C.,
Gollub Randy L.,
Heintges Judith,
Baumgartner Werner A.,
Rosen Bruce R.,
Gastfriend David R.
Publication year - 2000
Publication title -
the american journal on addictions
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.997
H-Index - 76
eISSN - 1521-0391
pISSN - 1055-0496
DOI - 10.1080/10550490050148044
Subject(s) - drug , carbohydrate deficient transferrin , cocaine use , psychology , clinical psychology , correlation , cocaine dependence , pharmacology , psychiatry , medicine , addiction , alcohol , alcohol consumption , biology , geometry , mathematics , biochemistry
Accurate estimate of drug exposure plays an important role in studies of the neurobiology of drug dependence. The validity of self‐reported drug use by subjects participating in such studies has not been well established. This study examined the relationship between self‐reported drug use and biological markers in 18 non‐treatment‐seeking cocaine‐dependent individuals participating in research on the effects of cocaine on the brain. A significant relationship was found between self‐reported frequency of cocaine use and hair cocaine concentration. Frequency of alcohol use correlated significantly with plasma carbohydrate‐deficient transferrin and aspartate aminotransferase levels. These results suggest that self‐reported substance use in non‐treatment seeking research subjects is generally valid.