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CO Sniffing through Heme‐based Sensor Proteins
Author(s) -
Ascenzi Paolo,
Bocedi Alessio,
Leoni Livia,
Visca Paolo,
Zennaro Elisabetta,
Milani Mario,
Bolognesi Martino
Publication year - 2004
Publication title -
iubmb life
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.132
H-Index - 113
eISSN - 1521-6551
pISSN - 1521-6543
DOI - 10.1080/10258140412331286937
Subject(s) - heme , signal transduction , chemistry , biochemistry , sniffing , hemeprotein , enzyme , methanogenesis , microbiology and biotechnology , biology , methane , neuroscience , organic chemistry
O2, NO, and CO are substrates, products, and/or modulators in many enzymatic reactions including O2 respiration, denitrification, N2 fixation, and methanogenesis. Over the last decade, O2, NO, and CO have been reported to act as signaling molecules in the control of several distinct biological functions. Here, the heme‐based mechanisms of CO sensing by the bacterial homodimeric CooA and the mammalian heterodimeric NPAS2‐BMAL1 transcriptional factors are reviewed, and the signal transduction pathways are discussed.IUBMB Life, 56: 309‐315, 2004