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Use of Selective Breeding in Alcohol Research
Author(s) -
Deitrich Richard A.
Publication year - 1988
Publication title -
australian drug and alcohol review
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.018
H-Index - 74
eISSN - 1465-3362
pISSN - 0819-5331
DOI - 10.1080/09595238880000051
Subject(s) - selective breeding , preference , alcohol , microbiology and biotechnology , biology , medicine , genetics , biochemistry , economics , microeconomics
The use of selective breeding in alcohol research is relatively recent in spite of the extensive use of the technique in other areas of behavioural research and the long history of selective breeding in agriculture. Initial efforts were directed toward selective breeding for acute effects and preference. More recently, selective breeding for ethanol activation, hypothermia, severity of withdrawal, tolerance and stress response as well as new breeding programs for preference and acute effects are underway. Related breeding programs for benzodiazepine and opiate sensitivity are also being carried out. The technique affords the opportunity to dissect the mechanism of the action of ethanol at the molecular level and the genetic basis of various ethanol effects.